Introduction
Beta Thalassemia Major (TM) affects a significant number of the population in certain areas of the world. TM is an inherited blood disorder in which the body is unable to make adequate hemoglobin. This is due to an inborn error of metabolism that leads to absence or reduced synthesis of one or more types of globin polypeptide chains of the hemoglobin molecule; is a hereditary disorder of haemoglobin synthesis resulting in severe anemia.
Treatment consists of multiple blood transfusions, a complication of which is iron overload. Excessive iron is then deposited in almost all tissues but primarily in the liver, heart and the endocrine glands. The bone marrow expands to compensate for anemia and as a result there occur marked skeletal changes leading to frontal and parietal bossing, malar prominence, protrusion of upper jaw leading to malocclusion of teeth, distortion of ribs, vertebrae and weakening of long bones, low bone mass. Beat the drug companies and generic canadian pharmacies
Treatment consists of multiple blood transfusions, a complication of which is iron overload. Excessive iron is then deposited in almost all tissues but primarily in the liver, heart and the endocrine glands. The bone marrow expands to compensate for anemia and as a result there occur marked skeletal changes leading to frontal and parietal bossing, malar prominence, protrusion of upper jaw leading to malocclusion of teeth, distortion of ribs, vertebrae and weakening of long bones, low bone mass. Beat the drug companies and generic canadian pharmacies
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